Pyrimidine ribonucleoside monophosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleoside monophosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FNDC3B_S208, IKBIP, and SRRM2_S2694, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside monophosphate metabolic process activity versus FNDC3B_S208 in LUAD (Pearson r = 0.25).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	FNDC3B_S208 →	+0.263	+0.037	.004	.001	3	5
OV	IKBIP →	+0.423	+0.044	.006	.004	3	5
BRCA	SRRM2_S2694 →	-0.298	-0.033	.007	.004	3	5
LUAD	AHNAK2_S4419 →	+0.488	+0.036	.008	.001	3	5
OV	WIPF1 →	+0.420	+0.041	.001	.001	3	4
LUAD	GPX8 →	+0.544	+0.052	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009173 vs FNDC3B_S208 — LUAD

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