Pyrimidine ribonucleoside monophosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine ribonucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ECT2L, SLC35F2, and IQCA1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside monophosphate metabolic process activity versus ECT2L in GBM (Pearson r = -0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	ECT2L →	-0.647	-0.221	<.001	<.001	3	4
HNSC	SLC35F2 →	+0.804	+0.177	<.001	<.001	3	4
LUAD	IQCA1 →	-0.529	-0.129	.006	.001	3	4
HNSC	MYOSLID →	+1.018	+0.168	<.001	.001	2	5
HNSC	DPYD-AS2 →	+0.840	+0.160	.001	<.001	3	4
LUAD	DCBLD2 →	+0.883	+0.229	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009173 vs ECT2L — GBM

Explore this scatter interactively →