Pyrimidine ribonucleoside monophosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine ribonucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are B4GALT1, CTSD, and ITGA5, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine ribonucleoside monophosphate metabolic process activity versus B4GALT1 in BLOOD_Lymphoma (Pearson r = -0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	B4GALT1 →	-1.355	-0.206	.009	.008	3	5
BLOOD_Lymphoma	CTSD →	-1.277	-0.193	<.001	.002	2	6
CNS	ITGA5 →	-1.620	-0.503	.004	.007	3	5
LUNG_SCLC	TBC1D2 →	-1.367	-0.268	<.001	.002	3	4
BLOOD_Lymphoma	CD99L2 →	-1.373	-0.206	<.001	.003	3	4
LUNG_SCLC	SLC35B2 →	-0.882	-0.246	.003	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009173 vs B4GALT1 — BLOOD_Lymphoma

Explore this scatter interactively →