Purine deoxyribonucleoside monophosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Purine deoxyribonucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBTB18, GDA, and VIL1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine deoxyribonucleoside monophosphate catabolic process activity versus ZBTB18 in CCRCC (Pearson r = 0.01).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ZBTB18 →	-0.381	-0.102	.002	.007	2	6
HNSC	GDA →	+1.378	+0.112	<.001	<.001	3	4
LUAD	VIL1 →	-0.953	-0.127	.002	.004	2	5
BRCA	SENP2 →	-0.319	-0.120	.001	<.001	3	4
UCEC	IL1RN →	+1.392	+0.178	<.001	<.001	3	4
BRCA	PAIP2B →	-0.720	-0.129	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009172 vs ZBTB18 — CCRCC

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