Purine deoxyribonucleoside monophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Purine deoxyribonucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PI4K2A, SLC2A1, and IFT140, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine deoxyribonucleoside monophosphate catabolic process activity versus PI4K2A in CNS (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PI4K2A →	-0.434	-1.150	.007	.007	2	8
LARGE_INTESTINE	SLC2A1 →	-2.029	-1.365	.007	<.001	3	5
OESOPHAGUS	IFT140 →	-1.148	-1.442	.002	<.001	3	4
CNS	HMGN5 →	+1.534	+1.273	<.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF330 →	+0.610	+1.382	.009	.009	2	5
LARGE_INTESTINE	BCL11A →	+2.395	+1.206	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009172 vs PI4K2A — CNS

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