Deoxyribonucleoside monophosphate metabolic process

pathway activity — cross-omics
GO:0009162Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Deoxyribonucleoside monophosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SNX20, IL21R, and ZBED2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
LUADSNX20 →+0.608+0.272<.001<.00137
OVIL21R →+0.674+0.144.003.00436
LUADZBED2 →+1.013+0.248<.001<.00135
LUADSLAMF8 →+0.638+0.249.001<.00135
UCECADGRG5 →+0.552+0.169.001<.00135
HNSCSH3BP1 →+0.654+0.085.001.00235
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration