Deoxyribonucleoside monophosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Deoxyribonucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSF2RB, PTAFR, and STK10, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleoside monophosphate catabolic process activity versus CSF2RB in OV (Pearson r = 0.23).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CSF2RB →	+1.173	+0.139	<.001	.003	3	7
UCEC	PTAFR →	+1.020	+0.199	<.001	<.001	3	7
OV	STK10 →	+0.707	+0.148	.002	.007	3	7
GBM	IL21R →	+0.817	+0.141	.005	.002	3	7
OV	ARHGAP9 →	+0.757	+0.139	<.001	<.001	3	7
OV	RAC2 →	+1.011	+0.123	<.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009159 vs CSF2RB — OV

Explore this scatter interactively →