Deoxyribonucleoside monophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Deoxyribonucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CMC2, VPS4A, and UBQLN1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CMC2 grouped by Deoxyribonucleoside monophosphate catabolic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CMC2 →	+0.670	+1.586	.003	<.001	3	5
KIDNEY	VPS4A →	+0.668	+1.322	<.001	.002	3	4
PANCREAS	UBQLN1 →	+0.762	+1.129	<.001	.001	3	4
LIVER	RBM44 →	+0.290	+1.368	.001	.009	3	4
CNS	CDCA2 →	+0.597	+0.801	.005	.005	3	4
KIDNEY	CSNK2A2 →	+0.755	+1.159	.006	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CMC2 by Deoxyribonucleoside monophosphate catabolic process activity — LIVER

Explore this box plot interactively →