Deoxyribonucleoside monophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Deoxyribonucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM127, ABLIM3, and PRKX, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleoside monophosphate catabolic process activity versus TMEM127 in LARGE_INTESTINE (Pearson r = -0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TMEM127 →	-0.792	-0.799	<.001	.004	3	6
CNS	ABLIM3 →	-1.664	-0.968	.009	.004	3	5
LARGE_INTESTINE	PRKX →	+0.883	+0.874	.007	.004	3	5
BLOOD_Leukemia	OS9 →	-0.615	-0.237	.001	.004	3	4
LARGE_INTESTINE	CPPED1 →	-1.315	-0.934	.008	<.001	3	4
LARGE_INTESTINE	ACTR3B →	+0.795	+1.171	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009159 vs TMEM127 — LARGE_INTESTINE

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