Deoxyribonucleoside monophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Deoxyribonucleoside monophosphate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DNPH1, CAD, and RTCB, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleoside monophosphate catabolic process activity versus DNPH1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	DNPH1 →	+1.560	+1.061	<.001	<.001	3	9
BONE	CAD →	+1.497	+1.286	<.001	<.001	3	7
LUNG_NSCLC_LUAD	RTCB →	+0.583	+0.685	.005	.006	2	8
LARGE_INTESTINE	TTLL12 →	+1.388	+1.051	.006	.001	3	7
LARGE_INTESTINE	HSP90AB2P →	+1.835	+1.024	.001	.003	3	7
BONE	SLC2A1 →	-2.338	-1.019	.001	.007	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009159 vs DNPH1 — UPPER_AERODIGESTIVE_TRACT

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