Ribonucleoside monophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Ribonucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ABCD4, C19orf47, and ASXL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ABCD4 grouped by Ribonucleoside monophosphate catabolic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ABCD4 →	-0.896	-1.292	<.001	.001	3	5
BLOOD_Lymphoma	C19orf47 →	+0.895	+1.985	.007	.006	3	4
URINARY_TRACT	ASXL1 →	+1.040	+1.661	.005	<.001	3	4
URINARY_TRACT	PLRG1 →	+0.886	+1.656	.001	<.001	3	4
OVARY	PEX2 →	-0.444	-0.723	.008	.003	3	4
BLOOD_Lymphoma	MBNL1 →	+0.554	+1.651	.008	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ABCD4 by Ribonucleoside monophosphate catabolic process activity — LUNG_SCLC

Explore this box plot interactively →