Ribonucleoside monophosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Ribonucleoside monophosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AVPI1, ANKRD26, and IP6K1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleoside monophosphate catabolic process activity versus AVPI1 in BLOOD_Myeloma (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	AVPI1 →	-0.655	-0.474	.001	.002	3	5
BLOOD_Myeloma	ANKRD26 →	+0.546	+0.426	.003	.004	3	4
BREAST	IP6K1 →	+0.566	+0.684	.002	.002	3	4
KIDNEY	SMARCC1 →	+1.529	+1.495	.004	.003	2	5
BLOOD_Myeloma	LIMD1 →	+0.645	+0.468	.009	.002	2	5
LUNG_NSCLC_LUAD	RASA1 →	+0.888	+0.639	.005	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009158 vs AVPI1 — BLOOD_Myeloma

Explore this scatter interactively →