Deoxyribonucleoside monophosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Deoxyribonucleoside monophosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PREX2, TONSL, and FBXO5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Deoxyribonucleoside monophosphate biosynthetic process activity versus PREX2 in GBM (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	PREX2 →	-0.467	-0.111	.002	.005	3	4
UCEC	TONSL →	+0.972	+0.281	<.001	<.001	3	4
UCEC	FBXO5 →	+0.652	+0.238	<.001	<.001	3	3
UCEC	BBS9 →	-0.343	-0.180	<.001	<.001	3	3
GBM	CYP2F2P →	-0.355	-0.139	.002	.003	3	3
PDAC	SSUH2 →	-0.302	-0.142	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009157 vs PREX2 — GBM

Explore this scatter interactively →