Deoxyribonucleoside monophosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Deoxyribonucleoside monophosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNKS, RPL11, and DOK4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNKS grouped by Deoxyribonucleoside monophosphate biosynthetic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	TNKS →	-0.710	-0.187	.003	.003	3	4
UPPER_AERODIGESTIVE_TRACT	RPL11 →	-0.662	-0.170	.003	.003	3	4
LARGE_INTESTINE	DOK4 →	+1.054	+0.214	.001	.003	3	4
PANCREAS	MYORG →	+1.413	+0.391	.006	.002	3	4
PANCREAS	TNFRSF6B →	+3.771	+0.276	<.001	.003	3	4
BREAST	SEMA3B →	+1.414	+0.207	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNKS by Deoxyribonucleoside monophosphate biosynthetic process activity — LIVER

Explore this box plot interactively →