Ribonucleoside monophosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Ribonucleoside monophosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GBP5, CXCL11, and ZNF683, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Ribonucleoside monophosphate biosynthetic process activity versus GBP5 in LUAD (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	GBP5 →	+0.821	+0.114	<.001	.002	3	4
LUAD	CXCL11 →	+1.240	+0.117	<.001	.006	3	4
LUAD	ZNF683 →	+0.490	+0.105	.002	.005	2	5
LUAD	CALHM6 →	+0.774	+0.146	.001	.003	3	4
LUAD	TBX21 →	+0.398	+0.106	<.001	.001	3	4
LSCC	SNX10 →	+0.646	+0.162	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009156 vs GBP5 — LUAD

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