Purine deoxyribonucleotide catabolic process

Across TCGA patient cohorts, RNA activity of the Purine deoxyribonucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD4, NCKAP1L, and SNX20, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine deoxyribonucleotide catabolic process activity versus CD4 in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CD4 →	+0.843	+0.206	.001	<.001	3	7
UCEC	NCKAP1L →	+0.967	+0.270	<.001	<.001	3	7
HNSC	SNX20 →	+0.721	+0.183	<.001	.001	3	7
HNSC	SIRPG →	+0.632	+0.143	<.001	<.001	3	7
UCEC	IL12RB1 →	+0.578	+0.234	.001	<.001	3	7
GBM	BTK →	+0.735	+0.188	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009155 vs CD4 — GBM

Explore this scatter interactively →