Purine deoxyribonucleotide catabolic process

Across TCGA cell cohorts, RNA activity of the Purine deoxyribonucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CNTNAP1, BSPRY, and ZNF641, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CNTNAP1 grouped by Purine deoxyribonucleotide catabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	CNTNAP1 →	+3.113	+1.721	.003	.002	3	4
URINARY_TRACT	BSPRY →	-3.093	-1.953	<.001	.001	3	4
URINARY_TRACT	ZNF641 →	-1.047	-1.653	.005	.004	3	4
URINARY_TRACT	LPAR2 →	-1.572	-1.686	.003	.004	3	4
LUNG_SCLC	TRIT1 →	-2.535	-1.210	<.001	<.001	3	4
BONE	SNRNP27 →	+0.498	+1.766	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CNTNAP1 by Purine deoxyribonucleotide catabolic process activity — URINARY_TRACT

Explore this box plot interactively →