Purine deoxyribonucleotide catabolic process

Across TCGA cell cohorts, RNA activity of the Purine deoxyribonucleotide catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSNK1G2, CD96, and CELSR1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine deoxyribonucleotide catabolic process activity versus CSNK1G2 in BLOOD_Myeloma (Pearson r = 0.67).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	CSNK1G2 →	+0.552	+0.318	<.001	.003	3	5
URINARY_TRACT	CD96 →	-0.996	-2.173	.001	.001	3	5
STOMACH	CELSR1 →	-2.173	-1.374	.006	.001	3	5
STOMACH	DNPH1 →	+1.367	+1.279	.005	.002	3	5
STOMACH	LITAF →	-1.184	-1.457	.004	.002	3	5
STOMACH	SLC22A4 →	-1.161	-1.556	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009155 vs CSNK1G2 — BLOOD_Myeloma

Explore this scatter interactively →