Purine deoxyribonucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Purine deoxyribonucleotide biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CRTAP, DCK, and CD276, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine deoxyribonucleotide biosynthetic process activity versus CRTAP in OV (Pearson r = -0.42).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CRTAP →	-0.465	-0.057	.001	.001	3	6
UCEC	DCK →	+0.390	+0.095	<.001	<.001	3	6
PDAC	CD276 →	-0.371	-0.066	<.001	<.001	3	6
BRCA	CNN3 →	-0.366	-0.037	.005	.004	3	6
PDAC	FLNA →	-0.396	-0.067	<.001	<.001	3	6
BRCA	ITGAV →	-0.520	-0.058	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009153 vs CRTAP — OV

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