Purine deoxyribonucleotide biosynthetic process

Across TCGA patient cohorts, RNA activity of the Purine deoxyribonucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LILRB1, TRBV29-1, and GFI1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine deoxyribonucleotide biosynthetic process activity versus LILRB1 in LUAD (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LILRB1 →	+0.387	+0.120	.002	<.001	3	4
GBM	TRBV29-1 →	+0.398	+0.166	.001	.006	3	4
UCEC	GFI1 →	+0.487	+0.097	.001	.002	3	4
LSCC	GMPS →	+0.652	+0.122	.003	.008	3	4
LSCC	HPS3 →	+0.507	+0.131	<.001	.002	3	4
LSCC	MAPKAP1 →	+0.418	+0.162	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009153 vs LILRB1 — LUAD

Explore this scatter interactively →