Purine deoxyribonucleotide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Purine deoxyribonucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2L6, FMN1, and CASK, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBE2L6 grouped by Purine deoxyribonucleotide biosynthetic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	UBE2L6 →	-1.392	-1.241	.001	<.001	3	4
BONE	FMN1 →	-1.099	-1.535	<.001	<.001	3	4
LUNG_NSCLC_LUAD	CASK →	-1.038	-0.899	.001	<.001	3	4
LUNG_NSCLC_LUAD	SPTBN1 →	-0.616	-0.646	.006	.003	2	5
LUNG_NSCLC_LUAD	PDZD7 →	-0.639	-0.742	.004	.004	3	4
BONE	ANOS1 →	-2.676	-1.643	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBE2L6 by Purine deoxyribonucleotide biosynthetic process activity — PANCREAS

Explore this box plot interactively →