Purine deoxyribonucleotide biosynthetic process

Across TCGA cell cohorts, RNA activity of the Purine deoxyribonucleotide biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GALC, HADH, and PYCR2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine deoxyribonucleotide biosynthetic process activity versus GALC in SKIN (Pearson r = -0.45).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GALC →	-1.830	-1.150	.004	.001	3	4
LUNG_NSCLC_LUAD	HADH →	+0.913	+1.235	<.001	<.001	3	4
LUNG_NSCLC_LUAD	PYCR2 →	+0.780	+1.119	.001	.001	3	4
LIVER	ERMP1 →	-1.672	-1.923	.001	<.001	3	4
STOMACH	STX2 →	+1.131	+1.542	.006	<.001	3	4
URINARY_TRACT	SLC25A22 →	+1.301	+1.938	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009153 vs GALC — SKIN

Explore this scatter interactively →