Purine deoxyribonucleotide metabolic process

Across TCGA patient cohorts, RNA activity of the Purine deoxyribonucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSMB10, SELPLG, and PTPN7, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine deoxyribonucleotide metabolic process activity versus PSMB10 in UCEC (Pearson r = 0.42).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMB10 →	+0.772	+0.190	<.001	.001	3	8
GBM	SELPLG →	+0.866	+0.205	.004	.003	3	7
HNSC	PTPN7 →	+0.587	+0.160	.002	<.001	3	7
GBM	SNX20 →	+0.818	+0.260	<.001	<.001	3	7
GBM	CD84 →	+1.186	+0.243	<.001	<.001	3	7
GBM	AIF1 →	+1.113	+0.262	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009151 vs PSMB10 — UCEC

Explore this scatter interactively →