Purine deoxyribonucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Purine deoxyribonucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GUK1, LZIC, and INTS10, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GUK1 grouped by Purine deoxyribonucleotide metabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	GUK1 →	-0.645	-1.563	.009	<.001	3	4
LARGE_INTESTINE	LZIC →	-0.544	-0.655	<.001	.004	3	4
LIVER	INTS10 →	+0.848	+1.248	.007	.005	2	5
BLOOD_Lymphoma	RBBP9 →	+0.983	+1.866	.003	<.001	3	4
BREAST	CDKN1A →	-1.942	-1.329	<.001	<.001	3	4
BREAST	IFT22 →	-0.873	-0.945	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GUK1 by Purine deoxyribonucleotide metabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →