Purine deoxyribonucleotide metabolic process

Across TCGA cell cohorts, RNA activity of the Purine deoxyribonucleotide metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ACTR3B, SLC22A4, and ADAM17, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine deoxyribonucleotide metabolic process activity versus ACTR3B in STOMACH (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ACTR3B →	+0.870	+1.488	.002	<.001	3	6
BREAST	SLC22A4 →	-0.927	-0.983	<.001	<.001	3	5
BLOOD_Myeloma	ADAM17 →	-0.864	-0.459	.003	.009	3	5
STOMACH	PPP3CC →	+0.731	+1.512	.006	.003	3	5
BLOOD_Leukemia	JPH1 →	+1.970	+0.421	<.001	.003	2	6
BLOOD_Leukemia	EHHADH →	-1.533	-0.408	<.001	.008	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009151 vs ACTR3B — STOMACH

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