Pyrimidine nucleoside triphosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside triphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C9orf40, PLK4, and MIS18A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside triphosphate biosynthetic process activity versus C9orf40 in HNSC (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	C9orf40 →	+0.686	+0.149	.001	.003	3	5
UCEC	PLK4 →	+0.667	+0.185	.002	.003	3	5
BRCA	MIS18A →	+0.334	+0.150	.008	.006	3	5
HNSC	RPL26P29 →	+0.865	+0.144	.003	.008	3	5
GBM	CLSPN →	+0.938	+0.181	.002	.004	3	5
UCEC	NEIL3 →	+0.653	+0.199	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009148 vs C9orf40 — HNSC

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