Pyrimidine nucleoside triphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside triphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ST3GAL2, NEU1, and NAGPA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ST3GAL2 grouped by Pyrimidine nucleoside triphosphate biosynthetic process-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	ST3GAL2 →	-1.171	-0.341	.007	.002	3	4
URINARY_TRACT	NEU1 →	-1.596	-1.906	<.001	.001	2	5
CNS	NAGPA →	-0.852	-0.781	.001	.003	3	4
BLOOD_Leukemia	SMIM3 →	-1.791	-0.374	.004	.004	3	4
BLOOD_Leukemia	STARD8 →	-2.303	-0.397	.005	.006	3	4
BLOOD_Leukemia	GIPC3 →	-1.252	-0.280	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ST3GAL2 by Pyrimidine nucleoside triphosphate biosynthetic process activity — LIVER

Explore this box plot interactively →