Pyrimidine nucleoside triphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside triphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LONP1, IMPDH2, and ATP5F1D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside triphosphate biosynthetic process activity versus LONP1 in OVARY (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LONP1 →	+1.066	+0.474	<.001	.007	3	5
BLOOD_Leukemia	IMPDH2 →	+0.395	+0.189	.005	<.001	3	5
BREAST	ATP5F1D →	+0.581	+0.462	<.001	.007	3	5
SKIN	TIMM44 →	+0.615	+0.198	.001	.001	3	4
SKIN	ENDOV →	+0.802	+0.229	.002	.005	3	4
LIVER	CISD1 →	+0.808	+0.338	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009148 vs LONP1 — OVARY

Explore this scatter interactively →