Pyrimidine nucleoside triphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC35A5, SLC39A14, and TTC14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SLC35A5 grouped by Pyrimidine nucleoside triphosphate metabolic process-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SLC35A5 →	-0.679	-0.693	<.001	.001	3	4
LUNG_SCLC	SLC39A14 →	-1.354	-0.330	.002	.002	2	4
LIVER	TTC14 →	-0.733	-0.223	.004	.004	3	3
LIVER	BCAR1 →	-1.551	-0.294	.002	.002	3	3
BLOOD_Leukemia	STARD8 →	-2.336	-0.343	.002	.007	3	3
BLOOD_Leukemia	PRRG1 →	-1.166	-0.308	.001	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SLC35A5 by Pyrimidine nucleoside triphosphate metabolic process activity — CNS

Explore this box plot interactively →