Pyrimidine nucleoside triphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPS2, PFAS, and ANKRD13B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside triphosphate metabolic process activity versus RPS2 in STOMACH (Pearson r = 0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	RPS2 →	+1.035	+0.601	.001	<.001	3	7
STOMACH	PFAS →	+1.120	+0.397	.005	.008	3	6
STOMACH	ANKRD13B →	+2.315	+0.653	<.001	.001	3	6
LUNG_SCLC	WDCP →	+0.725	+0.318	<.001	.001	3	6
UPPER_AERODIGESTIVE_TRACT	IMMT →	+0.978	+0.554	.002	.004	3	6
PANCREAS	XRCC5 →	+0.729	+0.452	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009147 vs RPS2 — STOMACH

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