Purine nucleoside triphosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside triphosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ETV7, TLDC2, and SAMHD1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside triphosphate catabolic process activity versus ETV7 in HNSC (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	ETV7 →	+0.848	+0.162	<.001	<.001	3	6
GBM	TLDC2 →	+0.483	+0.272	<.001	<.001	3	6
HNSC	SAMHD1 →	+1.047	+0.251	<.001	<.001	3	6
GBM	CD2 →	+1.223	+0.188	<.001	.008	3	6
UCEC	PLA2G2D →	+1.200	+0.264	<.001	.002	3	6
GBM	CXorf21 →	+0.986	+0.183	<.001	.006	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009146 vs ETV7 — HNSC

Explore this scatter interactively →