Purine nucleoside triphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside triphosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLA2G15, SREBF2, and PLEKHB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLA2G15 grouped by Purine nucleoside triphosphate catabolic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	PLA2G15 →	+1.031	+1.713	.001	<.001	2	5
PANCREAS	SREBF2 →	+1.360	+1.289	<.001	<.001	3	4
LUNG_SCLC	PLEKHB2 →	+0.839	+1.362	<.001	.002	3	4
BLOOD_Leukemia	BCAT2 →	-0.950	-1.927	<.001	<.001	3	4
BLOOD_Leukemia	WWC1 →	+1.526	+1.396	<.001	<.001	3	4
CNS	MAML1 →	+0.703	+1.330	.002	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLA2G15 by Purine nucleoside triphosphate catabolic process activity — OESOPHAGUS

Explore this box plot interactively →