Purine nucleoside triphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside triphosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SSR4, MEPCE, and MGME1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside triphosphate catabolic process activity versus SSR4 in OESOPHAGUS (Pearson r = 0.87).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	SSR4 →	+1.912	+1.912	.001	<.001	3	5
SOFT_TISSUE	MEPCE →	+0.569	+1.800	.006	<.001	3	4
CNS	MGME1 →	+0.601	+1.082	.006	<.001	3	4
BLOOD_Lymphoma	PWP1 →	+0.913	+1.292	.004	.002	3	4
BLOOD_Lymphoma	HSPB11 →	+1.291	+1.398	.001	<.001	3	3
BLOOD_Lymphoma	CRLS1 →	+0.754	+1.091	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009146 vs SSR4 — OESOPHAGUS

Explore this scatter interactively →