Purine nucleoside triphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside triphosphate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ITPA, PSMF1, and C20orf27, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside triphosphate catabolic process activity versus ITPA in STOMACH (Pearson r = 0.77).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	ITPA →	+2.029	+1.622	<.001	<.001	3	13
STOMACH	PSMF1 →	+1.370	+1.461	.003	<.001	3	9
STOMACH	C20orf27 →	+1.128	+1.437	.006	.003	3	9
LARGE_INTESTINE	PCNA →	+0.785	+0.839	.004	.002	3	8
BLOOD_Leukemia	SAMHD1 →	+1.874	+0.727	<.001	<.001	3	8
OESOPHAGUS	ESD →	+1.338	+1.054	.004	.006	2	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009146 vs ITPA — STOMACH

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