Nucleoside triphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside triphosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC30B, TTC30A, and FUZ, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TTC30B grouped by Nucleoside triphosphate catabolic process-low versus -high activity in URINARY_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	TTC30B →	-1.175	-1.497	<.001	.007	3	5
SKIN	TTC30A →	-0.626	-0.947	.002	.005	2	5
LIVER	FUZ →	-2.603	-1.247	<.001	.002	3	4
BLOOD_Leukemia	GOLGA8A →	-2.442	-0.875	.001	.006	3	4
BONE	RTL5 →	-1.321	-1.620	<.001	<.001	3	3
LARGE_INTESTINE	RPL34 →	+0.815	+1.334	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTC30B by Nucleoside triphosphate catabolic process activity — URINARY_TRACT

Explore this box plot interactively →