Nucleoside triphosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nucleoside triphosphate biosynthetic process pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MSH2, MDH2, and TFB2M, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside triphosphate biosynthetic process activity versus MSH2 in HNSC (Pearson r = 0.34).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	MSH2 →	+0.410	+0.066	<.001	<.001	3	6
HNSC	MDH2 →	+0.255	+0.061	.004	.001	3	6
LSCC	TFB2M →	+0.570	+0.042	<.001	<.001	3	6
LUAD	STMN1_S38 →	+0.570	+0.018	.004	.009	3	5
BRCA	TPX2_S738 →	+0.745	+0.022	.003	.003	3	5
LSCC	COIL_T303 →	+1.038	+0.031	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009142 vs MSH2 — HNSC

Explore this scatter interactively →