Nucleoside triphosphate biosynthetic process

Across TCGA patient cohorts, RNA activity of the Nucleoside triphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ELF2P1, KIDINS220, and BZW2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside triphosphate biosynthetic process activity versus ELF2P1 in LSCC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ELF2P1 →	-0.324	-0.089	.006	.004	3	5
LSCC	KIDINS220 →	-0.384	-0.141	.006	.003	3	4
UCEC	BZW2 →	-0.522	-0.143	<.001	<.001	3	4
UCEC	CMTM3 →	-0.477	-0.163	.001	<.001	3	4
UCEC	SEMA4C →	-0.584	-0.116	.001	.006	3	4
COAD	IL23A →	-0.569	-0.133	.009	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009142 vs ELF2P1 — LSCC

Explore this scatter interactively →