Nucleoside triphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nucleoside triphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CASP1, CDKN1A, and RASEF, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CASP1 grouped by Nucleoside triphosphate biosynthetic process-low versus -high activity in OESOPHAGUS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CASP1 →	-2.557	-0.221	.002	.003	3	5
SKIN	CDKN1A →	+1.756	+0.181	.002	.006	3	4
BREAST	RASEF →	+2.132	+0.406	<.001	<.001	3	4
OVARY	SLFN12 →	-1.290	-0.294	.008	.004	3	4
BREAST	FNDC3B →	-1.031	-0.255	.001	.001	3	4
UPPER_AERODIGESTIVE_TRACT	CPT1A →	+2.219	+0.336	.003	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CASP1 by Nucleoside triphosphate biosynthetic process activity — OESOPHAGUS

Explore this box plot interactively →