Nucleoside triphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Nucleoside triphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FGFR1OP2, LRP3, and PHTF2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside triphosphate biosynthetic process activity versus FGFR1OP2 in URINARY_TRACT (Pearson r = -0.57).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	FGFR1OP2 →	-0.876	-0.261	.002	.006	2	6
LUNG_NSCLC_LUAD	LRP3 →	+1.875	+0.246	.001	.002	3	5
BLOOD_Leukemia	PHTF2 →	-0.863	-0.245	<.001	<.001	3	5
BLOOD_Leukemia	UBALD1 →	+0.664	+0.230	.001	.002	3	5
URINARY_TRACT	PLPP5 →	-0.987	-0.313	.006	.008	3	4
LARGE_INTESTINE	ADAM9 →	-1.100	-0.204	.003	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009142 vs FGFR1OP2 — URINARY_TRACT

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