Nucleoside triphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Nucleoside triphosphate metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are LMNA_S407, PHRF1_S814, and TNS2_S931, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside triphosphate metabolic process activity versus LMNA_S407 in PDAC (Pearson r = -0.22).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	LMNA_S407 →	-0.632	-0.022	<.001	<.001	3	5
PDAC	PHRF1_S814 →	-0.438	-0.029	<.001	<.001	3	5
PDAC	TNS2_S931 →	+0.522	+0.021	.001	.001	3	4
GBM	ATPAF1 →	+0.277	+0.040	.003	<.001	3	4
PDAC	SRSF3_S5 →	-0.496	-0.029	<.001	<.001	3	4
GBM	WWTR1_S296 →	-0.380	-0.037	.003	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009141 vs LMNA_S407 — PDAC

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