Nucleoside triphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Nucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZNF286A, GPC2, and GAREM2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside triphosphate metabolic process activity versus ZNF286A in BRCA (Pearson r = -0.04).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ZNF286A →	-0.441	-0.136	<.001	.004	3	6
LSCC	GPC2 →	-0.726	-0.166	.001	<.001	3	6
LSCC	GAREM2 →	-1.007	-0.198	<.001	<.001	3	5
LSCC	MAP4K4 →	-0.433	-0.145	<.001	<.001	3	5
LSCC	TICRR →	-0.753	-0.168	<.001	<.001	3	5
BRCA	GJD4 →	-0.029	-0.143	.008	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009141 vs ZNF286A — BRCA

Explore this scatter interactively →