Nucleoside triphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Nucleoside triphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the OESOPHAGUS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM121, LRFN1, and FBF1, each associated with the pathway in up to 16 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nucleoside triphosphate metabolic process activity versus TMEM121 in OESOPHAGUS (Pearson r = 0.71).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	TMEM121 →	+1.888	+0.131	<.001	.001	3	16
LARGE_INTESTINE	LRFN1 →	+1.362	+0.063	<.001	.001	3	16
OESOPHAGUS	FBF1 →	+1.460	+0.118	<.001	<.001	3	15
SKIN	CCDC136 →	+1.791	+0.083	<.001	<.001	3	15
BONE	PCSK1N →	+2.524	+0.089	<.001	<.001	3	14
OESOPHAGUS	DUSP9 →	+1.884	+0.114	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009141 vs TMEM121 — OESOPHAGUS

Explore this scatter interactively →