Pyrimidine nucleoside diphosphate biosynthetic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside diphosphate biosynthetic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JUND, CARD19, and SELENOO, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JUND grouped by Pyrimidine nucleoside diphosphate biosynthetic process-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	JUND →	-1.100	-0.435	<.001	.002	3	3
LUNG_SCLC	CARD19 →	-0.772	-0.440	<.001	<.001	3	3
LUNG_SCLC	SELENOO →	-0.731	-0.528	.001	.003	3	3
LUNG_SCLC	MOCOS →	+1.324	+0.486	.006	.007	3	3
OESOPHAGUS	RPS16 →	+0.632	+0.265	<.001	.003	3	3
LARGE_INTESTINE	ATRAID →	-0.702	-0.321	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JUND by Pyrimidine nucleoside diphosphate biosynthetic process activity — LUNG_SCLC

Explore this box plot interactively →