Pyrimidine nucleoside diphosphate metabolic process

Across TCGA patient cohorts, RNA activity of the Pyrimidine nucleoside diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PPP2R2D, F2RL3, and SYNGR3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside diphosphate metabolic process activity versus PPP2R2D in PDAC (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	PPP2R2D →	-0.210	-0.132	.008	.002	3	5
PDAC	F2RL3 →	-0.563	-0.113	.002	.005	3	4
GBM	SYNGR3 →	-1.209	-0.137	<.001	<.001	3	4
GBM	N4BP3 →	-0.644	-0.096	<.001	.004	3	4
CCRCC	GRK4 →	-0.209	-0.167	<.001	<.001	3	3
CCRCC	RPS3A →	-0.342	-0.172	.004	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009138 vs PPP2R2D — PDAC

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