Pyrimidine nucleoside diphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GDE1, LYPD3, and SEC11C, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GDE1 grouped by Pyrimidine nucleoside diphosphate metabolic process-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	GDE1 →	-0.893	-0.191	<.001	<.001	3	4
LUNG_NSCLC_LUSC	LYPD3 →	+3.250	+0.314	.002	.007	3	4
LUNG_NSCLC_LUAD	SEC11C →	-1.182	-0.224	<.001	<.001	3	3
LUNG_NSCLC_LUSC	LYN →	+1.163	+0.304	<.001	.007	3	3
LUNG_NSCLC_LUAD	NCOA1 →	-0.568	-0.237	.004	<.001	3	3
LUNG_SCLC	TRAPPC12 →	-0.844	-0.397	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GDE1 by Pyrimidine nucleoside diphosphate metabolic process activity — PANCREAS

Explore this box plot interactively →