Pyrimidine nucleoside diphosphate metabolic process

Across TCGA cell cohorts, RNA activity of the Pyrimidine nucleoside diphosphate metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RUVBL1, TRIM22, and NOB1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Pyrimidine nucleoside diphosphate metabolic process activity versus RUVBL1 in BONE (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	RUVBL1 →	+0.838	+0.419	.006	.007	3	7
PANCREAS	TRIM22 →	-2.245	-0.974	.002	.008	3	6
BLOOD_Myeloma	NOB1 →	+0.759	+0.237	.008	<.001	2	6
OVARY	KLF16 →	+1.330	+0.383	<.001	<.001	2	6
BONE	MYC →	+2.960	+0.582	.007	.003	2	6
BONE	B3GALNT1 →	-3.344	-0.559	<.001	.002	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009138 vs RUVBL1 — BONE

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