Purine nucleoside diphosphate catabolic process

Across TCGA patient cohorts, RNA activity of the Purine nucleoside diphosphate catabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WDR43, NT5E, and RRP1B, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside diphosphate catabolic process activity versus WDR43 in LSCC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	WDR43 →	-0.323	-0.070	<.001	<.001	3	7
OV	NT5E →	+0.841	+0.079	<.001	<.001	3	7
OV	RRP1B →	-0.417	-0.066	.001	.006	3	6
GBM	SF3B6 →	-0.371	-0.125	<.001	<.001	3	6
OV	TBL3 →	-0.317	-0.065	.001	.001	3	6
LSCC	UTP15 →	-0.327	-0.072	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009137 vs WDR43 — LSCC

Explore this scatter interactively →