Purine nucleoside diphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside diphosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLCN7, ANTKMT, and EIF2AK4, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CLCN7 grouped by Purine nucleoside diphosphate catabolic process-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CLCN7 →	-0.981	-0.491	<.001	.002	3	5
UPPER_AERODIGESTIVE_TRACT	ANTKMT →	-1.198	-0.430	.002	.007	3	5
LUNG_NSCLC_LUSC	EIF2AK4 →	+0.873	+0.383	<.001	.001	3	5
LUNG_SCLC	GPX2 →	-5.003	-0.289	<.001	.005	3	4
LIVER	SLC25A10 →	-0.985	-0.377	<.001	.006	3	4
LUNG_SCLC	INPPL1 →	-1.477	-0.347	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CLCN7 by Purine nucleoside diphosphate catabolic process activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →