Purine nucleoside diphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside diphosphate catabolic process pathway is significantly associated with the shRNA dependency of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SMARCB1, TUBB, and ZNF362, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SMARCB1 grouped by Purine nucleoside diphosphate catabolic process-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SMARCB1 →	-0.251	-0.099	.008	<.001	3	5
LARGE_INTESTINE	TUBB →	+0.340	+0.055	.003	.002	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF362 →	-0.170	-0.112	<.001	<.001	3	4
LIVER	CDH16 →	+0.291	+0.121	<.001	.001	3	4
PANCREAS	TBC1D3F →	-0.245	-0.076	.001	.007	3	4
SOFT_TISSUE	H2AX →	-0.202	-0.078	.002	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SMARCB1 by Purine nucleoside diphosphate catabolic process activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →