Purine nucleoside diphosphate catabolic process

Across TCGA cell cohorts, RNA activity of the Purine nucleoside diphosphate catabolic process pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBC1D9, ENO2, and PDE6D, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Purine nucleoside diphosphate catabolic process activity versus TBC1D9 in LUNG_SCLC (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	TBC1D9 →	+0.880	+0.169	.005	.004	3	5
LUNG_SCLC	ENO2 →	+2.893	+0.260	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	PDE6D →	+0.952	+0.476	.004	.001	3	5
BREAST	HK1 →	+0.922	+0.278	.005	<.001	3	5
OVARY	MIF →	+0.886	+0.376	<.001	.002	3	5
BLOOD_Leukemia	ETFB →	+0.629	+0.183	.002	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0009137 vs TBC1D9 — LUNG_SCLC

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